Protein Modification Reagents
Medchemexpress LLC Fluorescein-PEG4-acid | 1807518-76-8 | 96.3% | 654.68 | 25 MG
Fluorescein-PEG4-acid is a PEG-based PROTAC linker. It can be used in the synthesis of PROTACs, which are compounds containing two different ligands connected by a linker. One ligand is for an E3 ubiquitin ligase and the other is for the target protein, exploiting the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
Cayman Chemical N 1-Carboxyethyl-L-lysIn 5mg
An advanced glycation end product; protein bound, but not free CEL, binds to RAGE; elevated in the lens of diabetic patients with cataract; decreases glutamate uptake and secretion of S100B in rat hippocampal slices in a RAGE-independent manner at 1 mM
eMolecules Medchem Express / Methyltetrazine-Ph-NHS ester / 50mg / 736630605 / HY-130283 / / 1644644-96-1 / MFCD28334557 / 327.300 / C15H13N5O4
Medchem Express / Methyltetrazine-Ph-NHS ester / 50mg / 736630605 / HY-130283 / / 1644644-96-1 / MFCD28334557 / 327.300 / C15H13N5O4
Gene Tools LLC Endo-Porter | DMSO formulation | 1mL
Endo-Porter is a novel peptide* explicitly designed to do what all existing peptide or lipid-based delivery reagents can not: deliver substances into the cytosol of cells by an endocytosis-mediated process that avoids damaging the plasma membrane of the cell. This mechanism prevents the loss of vital cell contents with its associated toxicity. Endo-Porter requires no interaction with the cargo to be delivered and allows the cargo that is endocytosed along with Endo-Porter to exit the endosome and enter the cytosol.
Medchemexpress LLC 4,7,10,13,16,19-hexaoxaeicosanoic acid | 1347750-72-4 | ≥95.0% | 324.37 g·mol⁻1 | C14H28O8 | 1 G
m-PEG5-CH2CH2COOH is a methoxy-terminated polyethylene glycol (PEG) linker with a terminal carboxylic acid used as a short, flexible spacer in PROTAC and bioconjugation chemistry.
- Methoxy-terminated PEG linker with terminal carboxylic acid.
- Suitable for PROTAC synthesis and bioconjugation.
- Purity: ≥95.0%.
- Molecular weight: 324.37 g·mol⁻1.
- CAS number: 1347750-72-4.
- Available in laboratory-scale package sizes, including 1 G.
Medchemexpress LLC Vh285-peg4-c4-cl | 1799506-07-2 | ≥98.0% | 799.42 | 10 MG
VH285-PEG4-C4-Cl is a conjugate of ligands for E3 and 16-atom-length linker. The connector of the linker is a halogen group. It incorporates a VH285 based VHL ligand and an alkyl/ether-based linker. It is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. It is able to induce 90% degradation of GFP-Halotag at 625 nM and binds to VHL with an IC50 of 0.54 μM.
- Functions as a conjugate of ligands for E3 and a 16-atom-length linker.
- Incorporates a VHL ligand and an alkyl/ether-based linker.
- Highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM.
- Able to induce 90% degradation of GFP-Halotag at 625 nM.
- Binds to VHL with an IC50 of 0.54 μM.
- Induces nearly complete knockdown of HaloTag7-ERK1 and HaloTag7-MEK1 at 500 nM.
Epigentek Inc DTT Solution (1 ml, 500 mM)
DTT, also known as Cleland's Reagent, is a particularly strong reducing agent, owing to its high conformational proprensity to form a six member ring with an internal disulfide bond. It has a redox potential of -0.33 V @ pH 7. It is used for many protein research applications, including reducing polyacrylamide electrophoresis (SDS-PAGE). The 500 mM stock solution can be directly used to achieve the amount of reducing agent required for your specific application.